Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Plaquenil eye toxicity Lucite plaquenil Hydroxychloroquine help with leg cramps Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. The DMARDs hydroxychloroquine and chloroquine are weak bases that accumulate in acidic compartments such as lysosomes and inflamed acidic tissues. Both hydroxychloroquine and chloroquine have a. Mechanism of action The precise mechanism by which hydroxychloroquine exhibits activity against Plasmodium is not known. Hydroxychloroquine, like chloroquine, is a weak base and may exert its effect by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine drug action Chloroquine Uses, Side Effects & Warnings -, Mechanisms of action of hydroxychloroquine and chloroquine. Sle hydroxychloroquineEffect of plaquenil on free light chainsPlaquenil tabs Plaquenil Hydroxychloroquine may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Drugs A-Z Pill Identifier Supplements Symptom Checker Diseases Dictionary Media Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. Plaquenil - FDA prescribing information, side effects and uses. Chloroquine Mode of Action Science. Chloroquine/hydroxychloroquine is extruded to the extracellular medium mostly by exocytosis and/or through the action of the multidrug resistance protein MRP-1, a cell surface drug transporter belonging to the ATP-binding cassette family, which also includes the more thoroughly studied P-glycoprotein. Chloroquine binds to heme or FP to form what is known as the FP-Chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-Chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion. In essence, the parasite cell drowns in its own metabolic products. Drug interactions Antacids - may reduce absorption of chloroquine. Kaolin - may reduce absorption of chloroquine. Cimetidine - may inhibit metabolism of chloroquine; increasing levels of chloroquine in the body. Ampicillin - levels may be reduced by chloroquine. Cyclosporine - levels may be.