Keep in mind that most people with Sjogren's stay healthy and don't have serious problems. You should be able to keep doing all the things you love to do without making many changes. Plaquenil-induced macular degeneration Delayed side effects plaquenil Coronary artery disease-- Stable cholesterol plaques in the heart's arteries can cause no symptoms or can cause chest pain called angina. Sudden cholesterol plaque rupture and clotting causes. Fatigue is one of the most common symptoms of fact, most people with lupus have fatigue at some point in their illness. “When lupus hit, it was like running into a wall at 80 mph. Plaquenil is NOT known to start working that fast. It takes anywhere from 4-6 months before the affects of Plaquenil are seen/felt. This is the case with everyone I know that takes it. My rheumy has saidand everything I've read on Plaquenil that Plaquenil NEEDS that amount of time to build in your system before it stats to have beneficial. Conditions like this are called autoimmune diseases. Sjogren's causes your immune system to go haywire and attack healthy cells instead of invading bacteria or viruses. Build up of plaquenil symptoms Plaquenil Uses, Dosage & Side Effects -, Fighting Lupus Fatigue and Boosting Energy Chloroquine phosphate and prazi proHydroxychloroquine dosing The most common side effects are diarrhea, nausea, vomiting, headache, dizziness, skin rash or black spots when you look at things. Most side effects will go away when your body gets used to the medicine. Tell your doctor if you have these side effects. A lower dose may stop them. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Immune & Autoimmune - Lupus Plaquenil - Can It Work Quickly?. Fuchs’ Dystrophy Treatments, Symptoms, and Stages. Plaque build-up can begin as early as the teenage years. By middle-age, problems begin to arise because blood flow becomes limited as a result. For example, many of the symptoms associated. For me it did not start so quickly. You need to build a therapeutic level for any real benefit. Sometimes that is how Sjogren's works. Symptoms seem to disappear for a few days and reappear. Plaquenil eventually helped my joint pain. The continued fatigue and other symptoms are related to my mctd so I am not the perfect judge for this. Though scalp buildup shares a lot of the same symptoms as dandruff, it's a different condition. And so, treating and preventing it usually requires a different approach.