Ototoxicity chloroquine

Discussion in 'Chloroquine' started by Mr.Fantastic, 12-Mar-2020.

  1. vrgames New Member

    Ototoxicity chloroquine


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Jun 27, 2007 Chloroquine CQ, a 4-aminoquinoline drug, has been largely used for the treatment of rheumatoid arthritis and other connective tissue diseases. Besides the well-known retinal toxicity, its use has been suspected of be associated to ototoxicity. Ototoxic chemicals are classified as neurotoxicants, cochleotoxicants, or vestibulotoxicants based on the part of the ear they damage, and they can reach the inner ear through the blood stream and cause injury to inner parts of the ear and connected neural pathways. 4 Neurotoxicants are ototoxic when they damage the nerve fibers that interfere. There are some reports about chloroquine-induced ototoxicity 7-9. Severe chloroquine-induced cochleovestibular toxicity was reported in a pregnant woman. Absence of inner and outer hair cells of the cochlea was also detected in a child whose mother took chloroquine during her pregnancy.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Ototoxicity chloroquine

    Chloroquine ototoxicity Request PDF - ResearchGate, Preventing Hearing Loss Caused by Chemical Ototoxicity.

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  7. The ototoxic effects can be minimized by carefully monitoring blood levels. Quinine. Chloroquine Phosphate Aralen Quinacrine Hydrochloride Atabrine Quinine Sulfate Quinam The ototoxic effects are very similar to those of aspirin.

    • American Ear Hearing and Audiology LLC - Ototoxic Medications..
    • A case report of hearing loss post use of..
    • Will you have Ototoxicity with Malaria - eHealthMe.

    Hearing loss can be even greater with exposure to both ototoxic chemicals and noise than exposure to either noise or the ototoxic chemical alone. 1 Many ototoxic substances have a greater-than-additive e.g. synergistic effect on hearing loss with noise exposure and in particular with impulse noise. 2 Several studies have suggested that some ototoxic chemicals, such as certain solvents. Jun 13, 2019 Ototoxicity is typically associated with bilateral high-frequency sensorineural hearing loss and tinnitus. Hearing loss can be temporary but is usually irreversible with most agents. Generally, antibiotic-induced ototoxicity is bilaterally symmetrical, but it can be asymmetrical. Mar 05, 2020 Quinine Aspirin and quinine are two of the most commonly available ototoxic medications. As you might know, aspirin is a blood thinner, as is quinine. This means that the oxygen brought to your ears is lessened, which can asphyxiate the hair cells.

     
  8. SpiderMaster Moderator

    Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. Early Plaquenil Toxicity Detected without Bull’s Eye. Liver problems - Symptoms and causes - Mayo Clinic Hydroxychloroquine-Induced Retinal Toxicity - American.
     
  9. Emil User

    Hydroxychloroquine as an anti-thrombotic in antiphospholipid. Hydroxychloroquine was suggested to play a role in lowering aPL antibody titers and preventing thrombotic recurrences in APS. 31, 32 In our study, the small proportions of hydroxychloroquine.

    Effect of Hydroxychloroquine on the Annexin A5 Resistance.