Plaquenil retinopathy risk factors

Discussion in 'Chloroquine Without A Doctors Prescription' started by ralan, 07-Mar-2020.

  1. REM_REM XenForo Moderator

    Plaquenil retinopathy risk factors


    One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus.

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    Jan 01, 2020 For individuals with significant risk factors daily dose of hydroxychloroquine sulfate greater than 5.0 mg/kg base of actual body weight, subnormal glomerular filtration, use of tamoxifen citrate or concurrent macular disease monitoring should include annual examinations which include BCVA, VF and SD-OCT. The new guidelines that came out in 2016 illustrated the most critical determinant of risk equals current excessive daily dose by actual weight in the following manner Uunder 5 mg/kg=2 percent risk over 10 years with an increase sharply to 20 percent at 20 years. 4 Furthermore, at 800 mg dosing, the daily risk would be 25 to 40 percent in one. Several factors have been associated with the risk of developing hydroxychloroquine retinopathy. One of the most important appears to be dosage—with debate over whether daily intake vs. cumulative dosage is most significant.

    It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress.

    Plaquenil retinopathy risk factors

    The risk of toxic retinopathy in patients on long-term., Determine risk for hydroxychloroquine retinal toxicity.

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  7. Our results show that the prevalence of hydroxychloroquine retinopathy is much higher than previously recognized and depends on risk factors such as daily dose, duration of use, and kidney disease. The results also suggest the need to revise the way that dosage is calculated to minimize risk.

    • The Risk of Toxic Retinopathy in Patients on Long-term..
    • Hydroxychloroquine-Induced Retinal Toxicity - American..
    • Risk Factors for Hydroxychloroquine and Chloroquine..

    In addition, toxic maculopathy has been reported to be dose dependent, whereby retinal toxicity risk increases with more than 6.5mg/kg of body weight. 6. Other risk factors include advanced age and pre-existing retinal disease. Patients with any of the aforementioned findings are considered “high risk” and should be monitored closely. The risk factors reported by the American Academy of the Ophthalmology AAO were compared between patients with n = 5 and without toxicity n = 26 findings. Risk score was calculated for each patient. Aug 29, 2014 Several risk factors may increase the likelihood of retinal toxicity from Plaquenil such as, age of greater than 60 years, daily dose more than 6.5 mg/kg; use of the drug more than 5 years, obesity, preexisting retinal disease and, renal or liver failure.

     
  8. niktron Moderator

    JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Facial Plastic Surgery JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959)Clinical images (left to right): fundus photography, spectral-domain optical coherence tomography (OCT), and 10-2 white target visual fields (pattern deviation plot and threshold plot). Plaquenil Guidelines Point Out New Risks, New Presentation. Comparison of Screening Procedures in Hydroxychloroquine. Rx Side Effects New Plaquenil Guidelines and More - American.
     
  9. OPS XenForo Moderator

    Hydroxychloroquine Retinopathy Still Alive and Well - The. May 16, 2011 Hydroxychloroquine Plaquenil; HCQ has been an important and effective drug for the treatment of lupus erythematosus and related autoimmune and inflammatory diseases for half a century, although its potential to cause retinal damage continues to raise concern among rheumatologists and ophthalmologists.

    Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy