One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Eye problems caused by plaquenil Plaquenil causes hair color change Malaria tablets chloroquine and proguanil side effects Jan 01, 2020 For individuals with significant risk factors daily dose of hydroxychloroquine sulfate greater than 5.0 mg/kg base of actual body weight, subnormal glomerular filtration, use of tamoxifen citrate or concurrent macular disease monitoring should include annual examinations which include BCVA, VF and SD-OCT. The new guidelines that came out in 2016 illustrated the most critical determinant of risk equals current excessive daily dose by actual weight in the following manner Uunder 5 mg/kg=2 percent risk over 10 years with an increase sharply to 20 percent at 20 years. 4 Furthermore, at 800 mg dosing, the daily risk would be 25 to 40 percent in one. Several factors have been associated with the risk of developing hydroxychloroquine retinopathy. One of the most important appears to be dosage—with debate over whether daily intake vs. cumulative dosage is most significant. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil retinopathy risk factors The risk of toxic retinopathy in patients on long-term., Determine risk for hydroxychloroquine retinal toxicity. Cost of plaquenil in australiaHow long should you take hydroxychloroquinePlaquenil shortage 2017Plaquenil to treat msAvastin hydroxychloroquine Our results show that the prevalence of hydroxychloroquine retinopathy is much higher than previously recognized and depends on risk factors such as daily dose, duration of use, and kidney disease. The results also suggest the need to revise the way that dosage is calculated to minimize risk. The Risk of Toxic Retinopathy in Patients on Long-term.. Hydroxychloroquine-Induced Retinal Toxicity - American.. Risk Factors for Hydroxychloroquine and Chloroquine.. In addition, toxic maculopathy has been reported to be dose dependent, whereby retinal toxicity risk increases with more than 6.5mg/kg of body weight. 6. Other risk factors include advanced age and pre-existing retinal disease. Patients with any of the aforementioned findings are considered “high risk” and should be monitored closely. The risk factors reported by the American Academy of the Ophthalmology AAO were compared between patients with n = 5 and without toxicity n = 26 findings. Risk score was calculated for each patient. Aug 29, 2014 Several risk factors may increase the likelihood of retinal toxicity from Plaquenil such as, age of greater than 60 years, daily dose more than 6.5 mg/kg; use of the drug more than 5 years, obesity, preexisting retinal disease and, renal or liver failure.