MTX monotherapy (MTG) is recommended as (part of) first choice treatment but no head-to-head comparisons are available comparing MTX–HCQ CTG with MTG. RA patients from the Sint Maartenskliniek and Radboudumc Nijmegen who started MTX with or without concomitant HCQ from April 2010 to October 2015 were included. Chloroquine in hepatic dysfunction Chloroquine based chalcone Avoid live virus vaccines with RA. It’s important to remember that those of us living with rheumatoid arthritis who use immunosuppressant medications, such as one of the biologics or methotrexate, should avoid receiving live virus vaccines for risk of developing the infection. This is why the shingles vaccine has been off limits. What Conditions Does This Treat? Originally, hydroxychloroquine was used to prevent and treat malaria and was considered very effective. Now it is generally used for rheumatoid arthritis, but it has also been shown to work well for juvenile arthritis, some lupus symptoms, and other types of autoimmune conditions. This is my first time at this forum. I was diagnosed with RA in April. I am taking plaquenil and methotrexate. The methotrexate has been working for a month or so. But, the side effects seem to be getting worse. I have headaches every day, and nausea from time to time, am tired all the time. Was considering going off of it. Afraid not to take. Regression modelling was used to correct for confounding. The primary outcome was the between-group ΔDAS28-CRP at 6 months, and secondary outcomes were ΔDAS28-CRP at 12 months, EULAR response at 6 and 12 months, and treatment intensification. Methotrexate vs plaquenil for ra Plaquenil vs. Rheumatrex, Trexall Prescription Treatment., RA and Hydroxychloroquine How Effective is it for. Hydroxychloroquine and bronchiecstasisHydroxychloroquine sulfate tablets usesPlaquenil e depressione Was the plaquenil controlling your RA symptoms? The trouble is you lose hair on Methotrexate too. But after losing heaps when I first went on it, I have stabalised now, I have thinner hair but it still looks fine and healthy. If plaq was working for your symptoms I'd go back on it. If you feel like the RA is escallating then go for mtx. Methotrexate vs Plaquenil? -. Bone Joint Muscle - Arthritis Plaquenil vs Methotroxate.. Compare Plaquenil vs Methotrexate -. This guide summarizes evidence comparing the effectiveness and safety of disease-modifying antirheumatic drugs DMARDs and corticosteroids used for rheumatoid arthritis RA. It does not address other drugs that are no longer commonly used as first-line treatment for RA, such as azathioprine, chloroquine, cyclosporine, gold, and penicillamine. Sorry to hear that you are having a lot of pain with your RA. I have lupus which mainly affects my joints and skin. I have been taking hydroxychloroquine which is the generic of plaquenil for the past three years. My rheumy recently added Imuran instead of methotrexate. Plaquenil hydroxychloroquine takes up to 3 months to begin working. My rheumy has officially decided today this is seronegative RA, and its time to start DMARDS to protect my joints. He's giving me a few weeks to do my homework though so that we can choose a medication for this. Basically he wants me to get through the holidays without medication symptoms. He wants me to look at plaquenil and methotrexate.