Affecting my self esteem Your definitely not alone. I’m fair hair n skin but I’m getting brown blotches. I am not looking to when it starts coming down my face hope I can b helped in time. Plaquenil success rheumatoid arthritis Fatcs on chloroquine Plaquenil for lupus weight loss Chloroquine dose for malaria prophylaxis Serious side effects are rare. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. Rarely, hydroxychloroquine can lead to anemia in some individuals. Find information about common, infrequent and rare side effects of Plaquenil Oral. Plaquenil can change the pigmentation in the skin, so it would stand to reason that it can do the same with hair. I have experienced the change in pigmentation on my legs. It looks like I have a huge bruise on the back of my leg which extends from the calf to the ankle. I call it a perma-bruise. My scalp has turned black and my forehead side of face r slowly turning ears r totally black shiny plate .various long and boring treatments from docs but to no avail.finally I have been asked to stopped taking h for lupus for 3 next step will b decided. I am surprised to hear about this cos my rheumy said hydroxy helps to lighten the skin. One of them is on my nose and people keep telling me I’ve a dirt mark. I'm from Indian sub continent and am a "woman of colour like urself" approx 2 years ago had sudden deep painful itch in scalp and body. Yes I have been on this med since 2003 and I have black patches all over. Plaquenil dark spots PATIENT FACT SHEET Hydroxychloroquine Plaquenil, Common and Rare Side Effects for Plaquenil Oral Hydroxychloroquine sulfate vs sodium bicarbonate Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. Long-Term Side Effects of Plaquenil for Rheumatoid.. Plaquinel changes hair color?" Lupus Community - Support.. Lupus-Specific Skin Disease and Skin Problems Johns.. Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong. Plaquenil received an overall rating of 5 out of 10 stars from 4 reviews. See what others have said about Plaquenil, including the effectiveness, ease of use and side effects. Plaquenil Reviews. One of the potential long-term side-effects of using anti-malarial medications such as hydroxychloroquine Plaquenil, chloroquine, and quinacrine is the development of dark-colored patches on the skin. They often appear brown, black, or black and blue and tend to develop on the legs, especially around the shins.