Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Plaquenil macular degeneration Purpose of plaquenil in lupus Irreversible retinal damage observed in some patients who had received hydroxychloroquine sulfate; significant risk factors for retinal damage include daily doses of hydroxychloroquine sulfate greater than 6.5 mg/kg 5 mg/kg base of actual body weight, durations of use greater than five years, subnormal glomerular filtration, use of some concomitant drug products such as tamoxifen citrate and concurrent macular disease The usual dose of Plaquenil is 400mg/day but 600mg/day is sometimes used as part of an induction regimen. It may be prescribed as a single daily dose or in divided doses twice per day. Usual Time to Effect Adult dosing ranges from 200 mg or 400 mg per day 6.5mg/kg. In some cases, higher doses can be used. It is recommended one tablet twice daily if taking more than one tablet. It is recommended to be taken with food. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil first dose Chloroquine Dosage Guide with Precautions -, Rheumatoid Arthritis Treatment Options Johns Hopkins. Chloroquine overdose amountHow much is plaquenilHydroxychloroquine for lichen sclerosus lichen planus eye side effectsVisual field test for hydroxychloroquine The first dose of Plaquenil is usually taken one to two weeks before traveling to an area where malaria is prevalent. Doses are then continued for four weeks after exposure. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Hydroxychloroquine Plaquenil. Chloroquine vs Hydroxychloroquine Comparison -. I've taken Plaquenil and while I initially had some slight dizziness, I reduced the dose to 200mg for a while and then never experienced the dizziness again, even after increasing the dose. Mg 310 mg base to 600 mg 465 mg base PO daily, administered as a single daily dose or in 2 divided doses. Do not exceed 600 mg/day 465 mg base/day or 6.5 mg/kg/day 5 mg base/kg/day, whichever is lower. Side effects may require a temporary initial dose reduction. The recommended initial dosage of hydroxychloroquine Plaquenil for the treatment of lupus erythematosus is 400 mg once or twice daily. The recommended maintenance dose range of hydroxychloroquine Plaquenil for the treatment of lupus erythematosus is 200 to 400 mg daily.