Burnetii and hematoxylin were used for staining; original magnification is ×50. This organism is uncommon, but may be found in cattle, sheep, goats, and other domestic mammals, including cats and dogs. The infection results from inhalation of a spore-like small-cell variant, and from contact with the milk, urine, feces, vaginal mucus, or semen of infected animals. The most common manifestation is flu-like symptoms with abrupt onset of fever, malaise, profuse perspiration, severe headache, muscle pain, joint pain, loss of appetite, upper respiratory problems, dry cough, pleuritic pain, chills, confusion, and gastrointestinal symptoms, such as nausea, vomiting, and diarrhea. Plaquenil drug information Plaquenil cause constipation Plaquenil pediatric dose Plaquenil is the brand name for the prescription drug hydroxychloroquine. For example, it may be combined with an antibiotic to treat chronic Q-fever. Q fever is caused by inhalation or ingestion of the bacterium Coxiella burnetii. People are most often exposed to the bacterium from the milk, urine and feces of infected animals for example, by inhaling contaminated air in a barnyard. Combination therapy with doxycycline and hydroxychloroquine is recommended for patients with chronic Q fever 10. Hydroxychloroquine is known to raise the pH of vacuoles that support C. burnetii. During its course, the disease can progress to an atypical pneumonia, which can result in a life-threatening acute respiratory distress syndrome, whereby such symptoms usually occur during the first four to five days of infection. About half of infected individuals exhibit no symptoms. Hydroxychloroquine q fever Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects., Q fever - NORD National Organization for Rare Disorders Plaquenil marijuanaFatigue plaquenilPlaquenil generic approval dateChloroquine for transduction hcmecHydroxychloroquine burrelia burgdorferi People living with chronic Q fever receive strong antibiotics and other medications, like hydroxychloroquine Plaquenil®, for several months. For some people, treatment lasts as long as 18 months. Throughout this time, your doctor continues to monitor you for any other medical issues that may arise. Q Fever Management and Treatment Cleveland Clinic. The Effect of pH on Antibiotic Efficacy against Coxiella.. Information for Healthcare Providers Q Fever CDC. Coxiella burnetii is the etiologic agent of Q fever. It is a small Gram-negative bacterium that grows only in eukaryotic cells 38. Within these cells it multiplies in an acidic vacuole, pH 4.8. However, for people who develop Q fever disease, treatment with 2 weeks of doxycycline antibiotic is recommended. Chronic Q fever. A life-threatening infection, requiring several months of antibiotic treatment. Treated with a combination of antibiotics including doxycycline and hydroxychloroquine for several months. Methods Between January 1987 and December 1997, the reference treatment of Q fever endocarditis was compared with one of doxycycline and hydroxychloroquine sulfate. Patients were treated by conventional therapy until May 1991 and then by the new regimen.