The patient had been on Amiodarone therapy for several years. These deposits occur in various levels of the cornea. Two months prior to this routine follow up, the patient's primary care doctor made a change in the patient's cardiac medications which included the removal of amiodarone from his medication regimen. Corneal verticillata, also called vortex keratopathy, are one type of corneal deposits. Chloroquine tablet dosage for adults Best way to take plaquenil Bpi nite burn and hydroxychloroquine Ocular signs cornea – vortex keratopathy - consists of grayish or golden brown corneal epithelial deposits. They are innocuous, completely reversible & not related to dose or duration. 50% patients may have decreased corneal sensation. They start at a point below the pupil & gradually swirl outwards sparing limbus. These deposits occur in various levels of the cornea. Corneal verticillata, also called vortex keratopathy, are one type of corneal deposits. Verticillata are readily recognizable by their distinct appearance as fine, golden-brown or gray opacities that are almost always bilateral. Corneal verticillata, or vortex keratopathy, manifests as a whorl-like pattern of golden brown or gray deposits in the inferior interpalpebal portion of the cornea in a clockwise fashion Fig 12-15. A variety of medications bind with the cellular lipids of the basal epithelial layer of the cornea due to their cationic, amphiphilic properties. The opacities branch out from a central whorl, usually across the inferior cornea. Verticillata are readily recognizable by their distinct appearance as fine, golden-brown or gray opacities that are almost always bilateral. Vortex keratopathy hydroxychloroquine Hydroxychloroquine - Wikipedia, Corneal verticillata - Amiodarone Plaquenil nail discoloration Toxicity from hydroxychloroquine may be seen in two distinct areas of the eye, the cornea, and the macula. The cornea may become affected relatively commonly by an innocuous vortex keratopathy characterized by whorl-like corneal epithelial deposits. Hydroxchloroquine and Chloroquine Toxicity - Eye Lessons. Corneal verticillata - American Academy of Ophthalmology. Newer technology advised for screening patients taking.. In 1 case related to perhexiline maleate, papilledema appearing concurrently with the vortex keratopathy and considered drug related resulted in significant visual acuity loss that did not completely reverse after withdrawal of the drug. 24 Besides asymptomatic vortex keratopathy, retinal toxicity—including macular and peripheral retina. Cornea verticillata. Contributor Jesse Vislisel, MD. Cornea verticillata, also known as vortex keratopathy, describes a pattern of whorl- shaped opacities within the basal corneal epithelium. They are most commonly located in the inferior paracentral region, are non-elevated, and can range from white to brown in color. Medications of the chloroquine family, including chloroquine Nivaquine, Avloclor, hydroxychloroquine Plaquenil, and amodiaquine, have been associated with keratopathy Srinivasan et al. 2011. Quinolone antimalarial drugs are used in the prophylaxis and treatment of malaria as well as in the treatment of certain rheumatological disorders e.